hla-drb and hla-dqb allele and haplotype frequencies in iranian patients with recurrent aphthous stomatitis
Authors
abstract
recurrent aphthous stomatitis (ras) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. ras appears to be associated with some human leukocyte antigen (hla) class ii alleles and haplotypes. this study attempts to survey the distribution of hla-drb and -dqb alleles among iranian ras patients and healthy controls. in order to evaluate the association of hla-dr and dq alleles and haplotypes, 54 patients with ras and 100 unrelated healthy subjects as control group were investigated. our data indicated that drb1*13:17, drb1*15:01, and drb5*01 were significantly more frequent in ras patients in comparison to controls. however, drb3:01allele frequency was higher in the controls compared to the patients. the significantly frequent allele in the patients compared with the healthy subjects was hla-dqb1*03:02. however, both hla-dqb1*02:01 and hla-dqb1*03:01 alleles were most frequent in the healthy individuals rather than the patients. the drb*04/dqb1*03:01 and drb*01:01/dqb1*02:01 haplotypes were significantly distributed in healthy subjects compared with patients. however, drb*07:01/dqb1*03:02 haplotype was found to be significantly frequent in patients than controls. in respect of hla genes, factors are involved in the incidence of ras; various hla-drb and hla-dqb1 alleles and the related haplotypes are suggested to be the three main ras susceptibility factors in our population study.
similar resources
HLA-DRB and HLA-DQB Allele and Haplotype Frequencies in Iranian Patients with Recurrent Aphthous Stomatitis.
Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate ...
full textHLA class II allele and haplotype frequencies in Iranian patients with leukemia.
Previous studies demonstrated significant differences in a number of HLA allele frequencies in leukemia patients and normal subjects. In this study, we have analyzed HLA class II alleles and haplotypes in 110 leukemia patients (60 acute myelogenous leukemia "AML", 50 chronic myelogenous leukemia"CML") and 180 unrelated normal subjects. Blood samples were collected from all of the patients and c...
full text"hla class ii allele and haplotype frequencies in iranian patients with acute myelogenous leukemia and control group "
previous studies have demonstrated some significant differences in hla allele frequencies in leukemic patients and normal subjects. we have analyzed hla class ii alleles and haplotypes in 60 iranian patients with acute myelogenous leukemia (aml) and 180 unrelated normal subjects. blood samples were collected after obtaining informed consents. from the patients and control dna extraction and hla...
full textRole of HLA class I (HLA-A, B) and HLA class II (HLA-DRB, DQB) in HIV-1 patients with and without pulmonary tuberculosis.
097. 642 | www.jaids.com q 2009 Lippincott Williams & Wilkins Letters to the Editor J Acquir Immune Defic Syndr Volume 51, Number 5, August 15, 2009
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of allergy, asthma and immunologyجلد ۱۵، شماره ۴، صفحات ۲۸۹-۲۹۵
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023